Fabrication of nanoscale zero-mode waveguides using microlithography for single molecule sensing
نویسندگان
چکیده
منابع مشابه
Fabrication of nanoscale zero-mode waveguides using microlithography for single molecule sensing.
We present a novel approach to the fabrication of zero-mode waveguides (ZMWs) using inexpensive processing techniques. Our method is capable of rapid fabrication of circular nanoapertures with diameters ranging from 70 nm to 2 μm, allowing us to perform a detailed characterization of the dependence of the fluorescence emission on the waveguide diameter. We also validated the use of the fabricat...
متن کاملAnalysis at High Concentrations Zero - Mode Waveguides for Single - Molecule
http://www.sciencemag.org/cgi/content/full/299/5607/682 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/299/5607/682/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...
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, 682 (2003); 299 Science et al. M. J. Levene Concentrations Zero-Mode Waveguides for Single-Molecule Analysis at High This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish ...
متن کاملZero-mode waveguides for single-molecule analysis at high concentrations.
Optical approaches for observing the dynamics of single molecules have required pico- to nanomolar concentrations of fluorophore in order to isolate individual molecules. However, many biologically relevant processes occur at micromolar ligand concentrations, necessitating a reduction in the conventional observation volume by three orders of magnitude. We show that arrays of zero-mode waveguide...
متن کاملLevene , Analysis at High Concentrations Zero - Mode Waveguides for Single - Molecule
http://www.sciencemag.org/cgi/content/full/299/5607/682 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/299/5607/682/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...
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ژورنال
عنوان ژورنال: Nanotechnology
سال: 2012
ISSN: 0957-4484,1361-6528
DOI: 10.1088/0957-4484/23/45/455301